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Small: a novel nano thermometer based on near infrared two zone rare earth fluorescence lifetime

wallpapers News 2020-11-13

temperature is the key factor to control or affect the behavior of biological system. In situ accurate measurement of temperature changes in organs or specific physiological processes is very important to reveal the process of life activities. Conventional contact temperature measurement methods such as thermocouple thermistor are not suitable for temperature detection in living organisms.

fluorescent nano temperature sensor is a kind of non-invasive temperature measurement method. Its non-contact high-resolution characteristics make it possible to apply them to temperature assessment in early diagnosis of some diseases to provide real-time temperature feedback in cancer thermotherapy. So far quantum dots organic dyes metal nanoparticles rare earth doped nanomaterials other inorganic hybrid phosphorescent materials have been reported to be used for temperature sensing. These nanomaterials usually measure temperature based on temperature sensitive spectral changes such as fluorescence peak position change dual b luminous intensity ratio change or temperature sensitive spectral peak width change. However due to the different absorption scattering coefficients of biological tissues the shape of fluorescence spectrum will change after penetrating the tissues which leads to the inaccuracy of temperature measurement in vivo. In addition the optical properties of different tissue types are different the optical properties of tissues will change with temperature which greatly increases the complexity of accurate measurement of fluorescence nano temperature in vivo. The fluorescence lifetime of

is an inherent property of fluorescent materials which is independent of probe concentration excitation power heterogeneity tissue penetration depth. Therefore the mode based on fluorescence lifetime temperature measurement is expected to achieve accurate temperature sensing in vivo. Recently Professor Chen Guanying's team of Harbin University of technology has realized accurate temperature sensing in vivo by using the temperature dependence of the fluorescence lifetime of Yb ions at 1000 nm. Designed synthesized NaYF4@NaYF4 : Yb3 Nd3 @CaF2 The core / shell / shell nanocrystals (13.5 nm in size) confine the thermal sensitive lanthanide ion pairs (neodymium ytterbium) in the middle layer which maximally shield the quenching effect of crystal defects surface defects in the core eliminate the potential damage of complex environment in the organism to the thermal sensitive layer. It is revealed that the energy back transfer process between Nd3 Yb3 is the key factor affecting the temperature sensitivity of the fluorescence lifetime the high sensitive temperature response of 1.4% C-1 of Yb fluorescence lifetime at 1000 nm is achieved. In addition the fluorescence lifetime probe has good physical chemical stability including light stability thermal cycling stability pH stability concentration stability. The nanocrystals were injected into the yeast infected mouse model to accurately measure the temperature of the probe injection area. This fluorescent lifetime nano thermometer is expected to be used in accurate temperature measurement of living animals which provides a new idea for accurate temperature sensing in vivo.


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